How does microdosing work?

Serotonin Receptors and Microdosing

Psychedelic substances act on the serotonin (5-HT) receptors in our brain. Serotonin receptors can be found throughout the human nervous system and govern many aspects of our being, including mood, thinking, and even bowel movements. Psychedelics bind most effectively to the 5HT-2A receptor in our brains, the receptors involved in learning, memory, and cognition. 

As a result, when consuming only a microdose of a psychedelic substance and thus avoiding the “classical trip” with visual disturbances, it is believed that the brain can focus solely on the cognitive boost caused by these receptors.

Psychedelic substances suitable for microdosing

  • Cannabis
  • Psilocybin
  • LSD
  • Banisteriopsis caapi, used to prepare the psychoactive beverage Ayahuasca
  • Mescaline 
  • Salvia divinorum